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Pathogenic CD4(+) T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

In the nonobese diabetic mouse, a predominant component of the autoreactive CD4(+) T cell repertoire is directed against the B:9-23 segment of the insulin B chain. Previous studies established that the majority of insulin-reactive T cells specifically recognize a weak peptide-MHC binding register wi...

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Detalhes bibliográficos
Main Authors: Mohan, James F., Calderon, Boris, Anderson, Mark S., Unanue, Emil R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804950/
https://ncbi.nlm.nih.gov/pubmed/24127484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130582
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