p53 Represses Class Switch Recombination to IgG2a through its Antioxidant Function

Immunoglobulin class switch recombination (CSR) occurs in activated mature B cells, and causes an exchange of the IgM isotype for IgG, IgE or IgA isotypes, which increases the effectiveness of the humoral immune response. DNA double-stranded breaks (DSBs) in recombining switch (S) regions, where CSR...

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Detalhes bibliográficos
Main Authors: Guikema, Jeroen E.J., Schrader, Carol E., Brodsky, Michael H., Linehan, Erin K., Richards, Adam, El Falaky, Nahla, Li, Daniel H., Sluss, Hayla K., Szomolanyi-Tsuda, Eva, Stavnezer, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235438/
https://ncbi.nlm.nih.gov/pubmed/20483782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904085
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