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Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

Trans-SNARE complexes catalyze fast synaptic vesicle fusion and bind complexin, but the function of complexin binding to SNARE complexes remains unclear. Here we show that in neuronal synapses, complexin simultaneously suppressed spontaneous fusion and activated fast Ca(2+)-evoked fusion. The dual f...

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Autores principales: Maximov, Anton, Tang, Jiong, Yang, Xiaofei, Pang, Zhiping P., Südhof, Thomas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235366/
https://ncbi.nlm.nih.gov/pubmed/19164751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1166505
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