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Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

Trans-SNARE complexes catalyze fast synaptic vesicle fusion and bind complexin, but the function of complexin binding to SNARE complexes remains unclear. Here we show that in neuronal synapses, complexin simultaneously suppressed spontaneous fusion and activated fast Ca(2+)-evoked fusion. The dual f...

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Autors principals: Maximov, Anton, Tang, Jiong, Yang, Xiaofei, Pang, Zhiping P., Südhof, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235366/
https://ncbi.nlm.nih.gov/pubmed/19164751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1166505
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