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Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

Cystic fibrosis patients suffer from chronic lung infection and inflammation due to the secretion of viscous sputum. Sputum viscosity is caused by extracellular DNA, some of which originates from the release of neutrophil extracellular traps (NETs). During NET formation neutrophil elastase (NE) part...

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Detalhes bibliográficos
Main Authors: Papayannopoulos, Venizelos, Staab, Doris, Zychlinsky, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235130/
https://ncbi.nlm.nih.gov/pubmed/22174830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028526
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