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Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to trap and kill pathogens extracellularly. Reactive oxygen species are required to initiate NET formation but the downstream molecular mechanism is unknown. We show that upon activation, neutrophil elastase (NE)...

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Detalles Bibliográficos
Main Authors: Papayannopoulos, Venizelos, Metzler, Kathleen D., Hakkim, Abdul, Zychlinsky, Arturo
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003309/
https://ncbi.nlm.nih.gov/pubmed/20974816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201006052
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