Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes for E6-AP, an ubiquitin ligase. A unique featu...

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Bibliographic Details
Main Authors: Daily, Jennifer L., Nash, Kevin, Jinwal, Umesh, Golde, Todd, Rogers, Justin, Peters, Melinda M., Burdine, Rebecca D., Dickey, Chad, Banko, Jessica L., Weeber, Edwin J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235088/
https://ncbi.nlm.nih.gov/pubmed/22174738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027221
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