Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes for E6-AP, an ubiquitin ligase. A unique featu...

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Κύριοι συγγραφείς: Daily, Jennifer L., Nash, Kevin, Jinwal, Umesh, Golde, Todd, Rogers, Justin, Peters, Melinda M., Burdine, Rebecca D., Dickey, Chad, Banko, Jessica L., Weeber, Edwin J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2011
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235088/
https://ncbi.nlm.nih.gov/pubmed/22174738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027221
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