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Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy

Spinal muscular atrophy (SMA), a motoneuron disease caused by a deficiency of the survival of motor neuron (SMN) protein, is characterized by motoneuron loss and muscle weakness. It remains unclear whether widespread loss of neuromuscular junctions (NMJs) is involved in SMA pathogenesis. We undertoo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ling, Karen K. Y., Gibbs, Rebecca M., Feng, Zhihua, Ko, Chien-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235013/
https://ncbi.nlm.nih.gov/pubmed/21968514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr453
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