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The Nucleotide-binding State of Microtubules Modulates Kinesin Processivity and the Ability of Tau to Inhibit Kinesin-mediated Transport

The ability of Tau to act as a potent inhibitor of kinesin's processive run length in vitro suggests that it may actively participate in the regulation of axonal transport in vivo. However, it remains unclear how kinesin-based transport could then proceed effectively in neurons, where Tau is ex...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McVicker, Derrick P., Chrin, Lynn R., Berger, Christopher L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234877/
https://ncbi.nlm.nih.gov/pubmed/22039058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292987
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