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The Nucleotide-binding State of Microtubules Modulates Kinesin Processivity and the Ability of Tau to Inhibit Kinesin-mediated Transport

The ability of Tau to act as a potent inhibitor of kinesin's processive run length in vitro suggests that it may actively participate in the regulation of axonal transport in vivo. However, it remains unclear how kinesin-based transport could then proceed effectively in neurons, where Tau is ex...

詳細記述

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書誌詳細
主要な著者: McVicker, Derrick P., Chrin, Lynn R., Berger, Christopher L.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234877/
https://ncbi.nlm.nih.gov/pubmed/22039058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.292987
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