Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

Type 1 diabetes is characterized by local inflammation (insulitis) in the pancreatic islets causing β-cell loss. The mitochondrial pathway of apoptosis is regulated by the balance and interaction between Bcl-2 members. Here we clarify the molecular mechanism of β-cell death triggered by the pro-infl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Barthson, Jenny, Germano, Carla M., Moore, Fabrice, Maida, Adriano, Drucker, Daniel J., Marchetti, Piero, Gysemans, Conny, Mathieu, Chantal, Nuñez, Gabriel, Jurisicova, Andrea, Eizirik, Decio L., Gurzov, Esteban N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234786/
https://ncbi.nlm.nih.gov/pubmed/21937453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.253591
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados