A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells

Type 1 diabetes is an autoimmune disease with a strong inflammatory component. The cytokines interleukin-1β and interferon-γ contribute to beta cell apoptosis in type 1 diabetes. These cytokines induce endoplasmic reticulum stress and the unfolded protein response (UPR), contributing to the loss of...

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Detalhes bibliográficos
Main Authors: Brozzi, Flora, Gerlo, Sarah, Grieco, Fabio Arturo, Nardelli, Tarlliza Romanna, Lievens, Sam, Gysemans, Conny, Marselli, Lorella, Marchetti, Piero, Mathieu, Chantal, Tavernier, Jan, Eizirik, Décio L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110279/
https://ncbi.nlm.nih.gov/pubmed/24936061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568808
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