Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells

Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes at least in part by inducing endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). It remains to be determined what causes the transition from “physiological” to “apoptotic” UPR...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Brozzi, Flora, Gerlo, Sarah, Grieco, Fabio Arturo, Juusola, Matilda, Balhuizen, Alexander, Lievens, Sam, Gysemans, Conny, Bugliani, Marco, Mathieu, Chantal, Marchetti, Piero, Tavernier, Jan, Eizirik, Décio L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933257/
https://ncbi.nlm.nih.gov/pubmed/27044747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704619
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