Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells

Pro-inflammatory cytokines contribute to pancreatic beta cell apoptosis in type 1 diabetes at least in part by inducing endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). It remains to be determined what causes the transition from “physiological” to “apoptotic” UPR...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Brozzi, Flora, Gerlo, Sarah, Grieco, Fabio Arturo, Juusola, Matilda, Balhuizen, Alexander, Lievens, Sam, Gysemans, Conny, Bugliani, Marco, Mathieu, Chantal, Marchetti, Piero, Tavernier, Jan, Eizirik, Décio L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933257/
https://ncbi.nlm.nih.gov/pubmed/27044747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704619
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