STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

Cytokines produced by islet-infiltrating immune cells induce β-cell apoptosis in type 1 diabetes. The IFN-γ-regulated transcription factors STAT1/IRF-1 have apparently divergent effects on β-cells. Thus, STAT1 promotes apoptosis and inflammation, whereas IRF-1 down-regulates inflammatory mediators....

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Detalhes bibliográficos
Main Authors: Moore, Fabrice, Naamane, Najib, Colli, Maikel L., Bouckenooghe, Thomas, Ortis, Fernanda, Gurzov, Esteban N., Igoillo-Esteve, Mariana, Mathieu, Chantal, Bontempi, Gianluca, Thykjaer, Thomas, Ørntoft, Torben F., Eizirik, Decio L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020778/
https://ncbi.nlm.nih.gov/pubmed/20980260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162131
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