Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator

The antitumor activities of the novel adenosine monophosphate-activated protein kinase (AMPK) activator, OSU-53, were assessed in in vitro and in vivo models of triple-negative breast cancer. OSU-53 directly stimulated recombinant AMPK kinase activity (EC(50), 0.3 μm) and inhibited the viability and...

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Detalhes bibliográficos
Main Authors: Lee, Kuen-Haur, Hsu, En-Chi, Guh, Jih-Hwa, Yang, Hsiao-Ching, Wang, Dasheng, Kulp, Samuel K., Shapiro, Charles L., Chen, Ching-Shih
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234749/
https://ncbi.nlm.nih.gov/pubmed/21917926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264598
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