Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

Nitroxoline is an antibiotic by chelating Zn(2+) and Fe(2+) from biofilm matrix. In this study, nitroxoline induced G1 arrest of cell cycle and subsequent apoptosis in prostate cancer cells through ion chelating-independent pathway. It decreased protein levels of cyclin D1, Cdc25A and phosphorylated...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chang, Wei-Ling, Hsu, Lih-Ching, Leu, Wohn-Jenn, Chen, Ching-Shih, Guh, Jih-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741862/
https://ncbi.nlm.nih.gov/pubmed/26447757
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