Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Hsu, Jui-Ling, Leu, Wohn-Jenn, Hsu, Lih-Ching, Liu, Shih-Ping, Zhong, Nan-Shan, Guh, Jih-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282052/
https://ncbi.nlm.nih.gov/pubmed/30555320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01223
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