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Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

Castration-resistant prostate cancer (CRPC) cells can resist many cellular stresses to ensure survival. There is an unmet medical need to fight against the multiple adaptive mechanisms in cells to achieve optimal treatment in patients. Para-toluenesulfonamide (PTS) is a small molecule that inhibited...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Hsu, Jui-Ling, Leu, Wohn-Jenn, Hsu, Lih-Ching, Liu, Shih-Ping, Zhong, Nan-Shan, Guh, Jih-Hwa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282052/
https://ncbi.nlm.nih.gov/pubmed/30555320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01223
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