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A Three-part Signal Governs Differential Processing of Gli1 and Gli3 Proteins by the Proteasome
The Gli proteins are the transcriptional effectors of the mammalian Hedgehog signaling pathway. In an unusual mechanism, the proteasome partially degrades or processes Gli3 in the absence of Hedgehog pathway stimulation to create a Gli3 fragment that opposes the activity of the full-length protein....
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234730/ https://ncbi.nlm.nih.gov/pubmed/21921029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274993 |
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