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A Three-part Signal Governs Differential Processing of Gli1 and Gli3 Proteins by the Proteasome
The Gli proteins are the transcriptional effectors of the mammalian Hedgehog signaling pathway. In an unusual mechanism, the proteasome partially degrades or processes Gli3 in the absence of Hedgehog pathway stimulation to create a Gli3 fragment that opposes the activity of the full-length protein....
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234730/ https://ncbi.nlm.nih.gov/pubmed/21921029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274993 |
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