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Targeting proteins for degradation

Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small pep...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Schrader, Erin K, Harstad, Kristine G, Matouschek, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228941/
https://ncbi.nlm.nih.gov/pubmed/19841631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.250
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