A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells

Effector memory T cells (T(EM)) do not cause graft-versus-host disease (GVHD), though why this is has not been elucidated. To compare the fates of alloreactive naive (T(N)) or memory (T(M)) T cells, we developed a model of GVHD in which donor T cells express a transgene-encoded TCR specific for an a...

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Detalhes bibliográficos
Main Authors: Juchem, Kathryn W., Anderson, Britt E., Zhang, Cuiling, McNiff, Jennifer M., Demetris, Anthony J., Farber, Donna L., Caton, Andrew J., Shlomchik, Warren D., Shlomchik, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234673/
https://ncbi.nlm.nih.gov/pubmed/21768295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-330035
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