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CD8(+) but not CD4(+) T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4(+) and CD8(+) T cells require direct leukemic contact to mediate GVL
Whether T-cell antigen receptors (TCR) on donor T cells require direct interactions with major histocompatibility complex class I or class II (MHCI/MHCII) molecules on target cells to mediate graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) is a fundamental question in allogeneic ste...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275040/ https://ncbi.nlm.nih.gov/pubmed/18223170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-125294 |
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