Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense

NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive oxidant intermediates (ROIs), suffer from life-thr...

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Main Authors: Vethanayagam, R. Robert, Almyroudis, Nikolaos G., Grimm, Melissa J., Lewandowski, David C., Pham, Christine T. N., Blackwell, Timothy S., Petraitiene, Ruta, Petraitis, Vidmantas, Walsh, Thomas J., Urban, Constantin F., Segal, Brahm H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233573/
https://ncbi.nlm.nih.gov/pubmed/22163282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028149
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