Monocyte and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice

Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which phagocytes are defective in the generation of superoxide anion and downstream reactive oxidant species, is characterized by severe bacterial and fungal infections and excessive inflammation. Although NADPH oxidase iso...

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Bibliographic Details
Main Authors: Grimm, Melissa J., Vethanayagam, R. Robert, Almyroudis, Nikolaos G., Dennis, Carly G., Khan, A. Nazmul H., D’Auria, Anthony, Singel, Kelly L., Davidson, Bruce A., Knight, Paul R., Blackwell, Timothy S., Hohl, Tobias M., Mansour, Michael K., Vyas, Jatin M., Röhm, Marc, Urban, Constantin F., Kelkka, Tiina, Holmdahl, Rikard, Segal, Brahm H.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622122/
https://ncbi.nlm.nih.gov/pubmed/23509361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202800
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