Monocyte and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice

Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which phagocytes are defective in the generation of superoxide anion and downstream reactive oxidant species, is characterized by severe bacterial and fungal infections and excessive inflammation. Although NADPH oxidase iso...

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Autores principales: Grimm, Melissa J., Vethanayagam, R. Robert, Almyroudis, Nikolaos G., Dennis, Carly G., Khan, A. Nazmul H., D’Auria, Anthony, Singel, Kelly L., Davidson, Bruce A., Knight, Paul R., Blackwell, Timothy S., Hohl, Tobias M., Mansour, Michael K., Vyas, Jatin M., Röhm, Marc, Urban, Constantin F., Kelkka, Tiina, Holmdahl, Rikard, Segal, Brahm H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622122/
https://ncbi.nlm.nih.gov/pubmed/23509361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202800
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