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Ranolazine reduces Ca(2+) overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts
Ranolazine is a clinically approved drug for treating cardiac ventricular dysrhythmias and angina. Its mechanism(s) of protection is not clearly understood but evidence points to blocking the late Na(+) current that arises during ischemia, blocking mitochondrial complex I activity, or modulating mit...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3233383/ https://ncbi.nlm.nih.gov/pubmed/21741479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2011.06.018 |
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