Reduced mitochondrial Ca(2+) loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts

Oxidative damage and impaired cytosolic Ca(2+) concentration ([Ca(2+)](cyto)) handling are associated with mitochondrial [Ca(2+)] ([Ca(2+)](mito)) overload and depressed functional recovery after cardiac ischemia-reperfusion (I/R) injury. We hypothesized that hearts from old guinea pigs would demons...

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Autori principali: Rhodes, Samhita S., Camara, Amadou K. S., Heisner, James S., Riess, Matthias L., Aldakkak, Mohammed, Stowe, David F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
Soggetti:
Integrative Cardiovascular Physiology and Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353793/
https://ncbi.nlm.nih.gov/pubmed/22140052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00533.2011
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