Modulation of mitochondrial bioenergetics in isolated guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection

Mitochondria are damaged by cardiac ischemia-reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against I/R injury. Guinea pig hearts (n=71) were perf...

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Detalhes bibliográficos
Main Authors: Aldakkak, Mohammed, Stowe, David F., Lesnefsky, Edward J, Heisner, James S., Chen, Qun, Camara, Amadou K.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774837/
https://ncbi.nlm.nih.gov/pubmed/19620879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181b2b842
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