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Enhanced Na(+)/H(+) Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function
Inhibition of Na(+)/H(+) exchange (NHE) during ischemia reduces cardiac injury due to reduced reverse mode Na(+)/Ca(2+) exchange. We hypothesized that activating NHE-1 at buffer pH 8 during ischemia increases mitochondrial oxidation, Ca(2+) overload and reactive O(2) species (ROS) levels, and worsen...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659015/ https://ncbi.nlm.nih.gov/pubmed/18806604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181831337 |
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