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Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine

Ranolazine (Ran), an anti-anginal drug, is a late Na(+) channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia. In this study, we investigated if Ran's protective effect against cardiac ischemi...

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Detalhes bibliográficos
Main Authors: Gadicherla, Ashish K., Stowe, David F., Antholine, William E., Yang, Meiying, Camara, Amadou K.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269517/
https://ncbi.nlm.nih.gov/pubmed/22178605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2011.11.021
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