FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

FMRP loss-of-function causes Fragile X Syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but there has been little consensus regarding either its RNA targets or mechanism of ac...

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Autors principals: Darnell, Jennifer C., Van Driesche, Sarah J., Zhang, Chaolin, Hung, Ka Ying Sharon, Mele, Aldo, Fraser, Claire E., Stone, Elizabeth F., Chen, Cynthia, Fak, John J., Chi, Sung Wook, Licatalosi, Donny D., Richter, Joel D., Darnell, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232425/
https://ncbi.nlm.nih.gov/pubmed/21784246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.013
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