The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD). Using a reverse genetic screen in yeast, we...

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Udgivet i:eLife
Main Authors: D'Orazio, Karole N, Wu, Colin Chih-Chien, Sinha, Niladri, Loll-Krippleber, Raphael, Brown, Grant W, Green, Rachel
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598757/
https://ncbi.nlm.nih.gov/pubmed/31219035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49117
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