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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
Messenger RNAs harboring nonsense codons (or premature translation termination codons [PTCs]) are degraded by a conserved quality-control mechanism known as nonsense-mediated mRNA decay (NMD), which prevents the accumulation of truncated and potentially harmful proteins. In Drosophila melanogaster,...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590965/ https://ncbi.nlm.nih.gov/pubmed/18974281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1386208 |
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