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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

Messenger RNAs harboring nonsense codons (or premature translation termination codons [PTCs]) are degraded by a conserved quality-control mechanism known as nonsense-mediated mRNA decay (NMD), which prevents the accumulation of truncated and potentially harmful proteins. In Drosophila melanogaster,...

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Detalhes bibliográficos
Main Authors: Huntzinger, Eric, Kashima, Isao, Fauser, Maria, Saulière, Jérôme, Izaurralde, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590965/
https://ncbi.nlm.nih.gov/pubmed/18974281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1386208
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