A carregar...

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS). FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of the hippocampus, we find that ribosome footprint levels in Fmr1-deficient tissue mostly reflect changes in RNA abundance....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Shah, Sneha, Molinaro, Gemma, Liu, Botao, Wang, Ruijia, Huber, Kimberly M., Richter, Joel D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179797/
https://ncbi.nlm.nih.gov/pubmed/32234480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.076
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!