Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP

BACKGROUND: Mutations in TSC2 are the most common cause of tuberous sclerosis (TSC), a disorder with a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-dependent synaptic long-term depression (mGluR-LTD) and be...

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Bibliographic Details
Published in:Mol Autism
Main Authors: Hien, Annie, Molinaro, Gemma, Liu, Botao, Huber, Kimberly M., Richter, Joel D.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556950/
https://ncbi.nlm.nih.gov/pubmed/33054857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00384-9
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