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Transmembrane mutations in Toll-like Receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation
Recognition of nucleic acids as a signature of infection by Toll-like receptors (TLRs) 7 and 9 exposes the host to potential self-recognition and autoimmunity. It has been proposed that intracellular compartmentalization is largely responsible for reliable self versus non-self discrimination by thes...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230302/ https://ncbi.nlm.nih.gov/pubmed/22078797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.10.009 |
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