Directing the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approach

Heparan sulfate (HS) and heparin are highly sulfated polysaccharides exhibiting essential physiological functions. The sulfation patterns determine the functional selectivity for HS and heparin. Chemical synthesis of HS, especially those larger than a hexasaccharide, remains challenging. Enzymatic s...

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Bibliographic Details
Main Authors: Xu, Yongmei, Wang, Zhen, Liu, Renpeng, Bridges, Arlene S, Huang, Xuefei, Liu, Jian
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230279/
https://ncbi.nlm.nih.gov/pubmed/21835782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwr109
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