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Convergent Chemoenzymatic Synthesis and Biological Evaluation of a Heparan Sulfate Proteoglycan Syndecan-1 Mimetic
A new convergent chemoenzymatic synthesis strategy, integrating enzymatic synthesis of heparan sulfate, sortase A ligation, copper(I)-catalyzed alkyne-azide cycloaddition, and solid phase peptide synthesis, has been established to efficiently synthesize a mimetic of heparan sulfate proteoglycan synd...
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| Publié dans: | Chem Commun (Camb) |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052682/ https://ncbi.nlm.nih.gov/pubmed/33687395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1cc00796c |
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