One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

A wide variety of small molecules with diverse molecular scaffolds inhibit microtubule formation. In this article we report a one-pot procedure for the preparation of a novel 2-(N-pyrrolidinyl)-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole in which the size of the substituent at the C-2 position of...

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Detalhes bibliográficos
Main Authors: Romagnoli, Romeo, Baraldi, Pier Giovanni, Cara, Carlota Lopez, Salvador, Maria Kimatrai, Bortolozzi, Roberta, Basso, Giuseppe, Viola, Giampietro, Balzarini, Jan, Brancale, Andrea, Fu, Xian-Hua, Li, Jun, Zhang, Su-Zhan, Hamel, Ernest
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230238/
https://ncbi.nlm.nih.gov/pubmed/22027100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.10.013
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