Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

Because overactivation of the hypothalamic–pituitary–adrenal (HPA) axis occurs in Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic role in the pathophysiology of AD. However, the effects of stress on tau phosphorylation are poorly understood, and the relat...

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Autors principals: Carroll, Jenna C., Iba, Michiyo, Bangasser, Debra A., Valentino, Rita J., James, Michael J., Brunden, Kurt R., Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230070/
https://ncbi.nlm.nih.gov/pubmed/21976528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3836-11.2011
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