Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could lead to a loss of this function with consequen...

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Autori principali: Brunden, Kurt R., Zhang, Bin, Carroll, Jenna, Yao, Yuemang, Potuzak, Justin S., Hogan, Anne-Marie L., Iba, Michiyo, James, Michael J., Xie, Sharon X., Ballatore, Carlo, Smith, Amos B., Lee, Virginia M.-Y., Trojanowski, John Q.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2010
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958430/
https://ncbi.nlm.nih.gov/pubmed/20943926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3059-10.2010
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