Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could lead to a loss of this function with consequen...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Brunden, Kurt R., Zhang, Bin, Carroll, Jenna, Yao, Yuemang, Potuzak, Justin S., Hogan, Anne-Marie L., Iba, Michiyo, James, Michael J., Xie, Sharon X., Ballatore, Carlo, Smith, Amos B., Lee, Virginia M.-Y., Trojanowski, John Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2010
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958430/
https://ncbi.nlm.nih.gov/pubmed/20943926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3059-10.2010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky