Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau misfolding could lead to a loss of this function with consequen...

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Detalhes bibliográficos
Main Authors: Brunden, Kurt R., Zhang, Bin, Carroll, Jenna, Yao, Yuemang, Potuzak, Justin S., Hogan, Anne-Marie L., Iba, Michiyo, James, Michael J., Xie, Sharon X., Ballatore, Carlo, Smith, Amos B., Lee, Virginia M.-Y., Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958430/
https://ncbi.nlm.nih.gov/pubmed/20943926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3059-10.2010
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