A Novel PTEN-Dependent Link to Ubiquitination Controls FLIP(S) Stability and TRAIL Sensitivity in Glioblastoma Multiforme

Phosphatase and tensin homologue (PTEN) loss and activation of the Akt-mammalian target of rapamycin (mTOR) pathway increases mRNA translation, increases levels of the antiapoptotic protein FLIP(S), and confers resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)–induced apo...

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Hlavní autoři: Panner, Amith, Crane, Courtney A., Weng, Changjiang, Feletti, Alberto, Parsa, Andrew T., Pieper, Russell O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229302/
https://ncbi.nlm.nih.gov/pubmed/19808964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1287
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