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USP8 links the PTEN-Akt-AIP4 pathway to the control of FLIP(S) stability and TRAIL sensitivity in glioblastoma multiforme

The anti-apoptotic protein FLIP(S) is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homolog (PTEN)-Akt-atrophin interacting protein 4 (AIP...

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Autors principals: Panner, Amith, Crane, Courtney A., Weng, Changjiang, Feletti, Alberto, Fang, Shanna, Parsa, Andrew T., Pieper, Russell O.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891229/
https://ncbi.nlm.nih.gov/pubmed/20484045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3979
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