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A Novel PTEN-Dependent Link to Ubiquitination Controls FLIP(S) Stability and TRAIL Sensitivity in Glioblastoma Multiforme
Phosphatase and tensin homologue (PTEN) loss and activation of the Akt-mammalian target of rapamycin (mTOR) pathway increases mRNA translation, increases levels of the antiapoptotic protein FLIP(S), and confers resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)–induced apo...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229302/ https://ncbi.nlm.nih.gov/pubmed/19808964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1287 |
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