Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphim...

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Autors principals: Ponder, Jessica, Yoo, Byong Hoon, Abraham, Adedoyin D., Li, Qun, Ashley, Amanda K., Amerin, Courtney L., Zhou, Qiong, Reid, Brian G., Reigan, Philip, Hromas, Robert, Nickoloff, Jac A., LaBarbera, Daniel V.
Format: Artigo
Idioma:Inglês
Publicat: Molecular Diversity Preservation International 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229241/
https://ncbi.nlm.nih.gov/pubmed/22163192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md9112397
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